Current Projects
A National Trial of the ELM Lifestyle Program and Remission of the Metabolic Syndrome
This is a multi-site randomized controlled trial of a lifestyle intervention designed to reverse the metabolic syndrome. The trial is led by Dr. Lynda Powell, and funded by the William G. McGowan Charitable Fund. The project will enroll up to 600 patients with metabolic syndrome at 5 sites in different regions of the U.S. The primary outcomes are reversal of the metabolic syndrome at 2 years, and cost-effectiveness of the group-based lifestyle intervention relative to a self-directed intervention.
Principal Investigator: Lynda Powell, PhD
Sponsor: William G. McGowan Charitable Fund
Recruitment status: Currently recruiting
Virtual Lifestyle Program to Boost Host Resistance in Patients with Elevated Cardiometabolic Risk: A Proof-of-Concept Study
This is a proof-of-concept study of a virtual version of a lifestyle intervention aimed at reducing cardiometabolic risk in patients with the metabolic syndrome (MetS). The aim is to recruit 12 patients at high risk for coronavirus infection based upon a diagnosis of obesity and the MetS, conduct a 12-week virtual version of the in-person intervention, and explore efficacy using clinically significant standards for weight, diet, physical activity, stress, and markers of inflammation. In addition, we will explore safety, fidelity, feasibility, and acceptability. The infrastructure from the ongoing multi-site trial will be drawn upon to conduct virtual eligibility, recruitment, and outcomes assessment.
Principal Investigator: Lynda Powell, PhD
Sponsor: Rush Coronavirus Research Fund Awards
Recruitment status: Complete
Past Projects
Eat better, Love better, Move more (ELM): Designing a Lifestyle intervention for Prevention of Diastolic Heart Failure
The major goals of this “proof-of-concept” study were to evaluate factors associated with early diastolic dysfunction and pilot test lifestyle intervention for the remission of metabolic syndrome.
Principal Investigator: Lynda Powell, PhD
Sponsor: William G. McGowan Charitable Fund
Planning Grant: Expanding Access to ELM Program
This two-year planning grant set the stage for a multi-site trial of the ELM Program, a lifestyle intervention for metabolic syndrome. The Rush team formed a network of clinical research partnerships, developed plans for site-specific implementation of the ELM intervention, created a secure bidirectional data transfer system, trained remote intervention staff, and produced an intervention manual and study protocol for the subsequent trial.
Principal Investigator: Lynda Powell, PhD
Sponsor: William G. McGowan Charitable Fund