Department of Physiology & Biophysics

Dirk Gillespie, PhD is now a professor. Congratulations on his promotion!

The National Heart, Lung, and Blood Institute awarded Lothar A. Blatter, MD, Dr.med. (Physiology & Biophysics) and Kathrin Banach, PhD (Cardiology/Internal Medicine) a $2.7 million grant (R01HL164453) to conduct research on the mechanism of electrical and calcium alternans in the atria. Alternans is defined as beat-to-beat alternations in action potential duration (electrical alternans), contraction strength and calcium transient amplitude. Cardiac alternans is a recognized risk factor for cardiac arrhythmia, including atrial fibrillation. This study seeks to investigate the conditions that cause and sustain atrial alternans, and to determine cellular mechanisms of alternans in individual atrial myocytes, in multicellular tissue and at organ level, and to explore therapeutic interventions that reduce alternans risk.

Grant on NIH Reporter - Read More...

Carolina Figueroa, PhD is now an assistant professor. Congratulations on her promotion!

Carlo Manno, PhD is now an assistant professor. Congratulations on his promotion!

The National Heart, Lung, and Blood Institute awarded Lothar A. Blatter, MD, Dr.med. (Physiology & Biophysics) and Kathrin Banach, PhD (Cardiology/Internal Medicine) a $2.7 million grant to research of calcium regulation in the atria that controls activity and contraction, but also arrhythmic activity and atrial fibrillation. In the heart contraction is controlled by calcium ions that are released from intracellular calcium stores. This calcium release occurs through two different ion channels, termed the ryanodine receptor and the IP3 receptor. The importance of the IP3 receptor is controversial, however there is growing evidence, established by the PIs of this study, that IP3 receptor dysfunction causes atrial rhythm disorders. In this study the PIs will investigate the novel hypothesis that atrial IP3 receptors are co-regulated by the cellular messenger IP3 and reactive oxygen species in defined cellular signaling domains. The understanding of the IP3 receptor regulatory mechanisms will provide the basis for the development of novel strategies for prevention and treatment of atrial fibrillation.

Rush Announcement - Read More...

Grant on NIH Reporter - Read More...

Josefina Ramos-Franco, MD, PhD is now an associate professor. Congratulations on her promotion!

Lothar A. Blatter, M.D., Dr.med., was named the John H. and Margaret V. Krehbiel Professor of Cardiology, effective December 1, 2021.
Rush University News - Read More…

Dirk Gillespie, PhD is now a professor. Congratulations on his promotion!

The National Heart, Lung, and Blood Institute awarded Lothar A. Blatter, MD, Dr.med. (Physiology & Biophysics) and Kathrin Banach, PhD (Cardiology/Internal Medicine) a $2.7 million grant (R01HL164453) to conduct research on the mechanism of electrical and calcium alternans in the atria. Alternans is defined as beat-to-beat alternations in action potential duration (electrical alternans), contraction strength and calcium transient amplitude. Cardiac alternans is a recognized risk factor for cardiac arrhythmia, including atrial fibrillation. This study seeks to investigate the conditions that cause and sustain atrial alternans, and to determine cellular mechanisms of alternans in individual atrial myocytes, in multicellular tissue and at organ level, and to explore therapeutic interventions that reduce alternans risk.

Grant on NIH Reporter - Read More...

Carolina Figueroa, PhD is now an assistant professor. Congratulations on her promotion!

Carlo Manno, PhD is now an assistant professor. Congratulations on his promotion!

The National Heart, Lung, and Blood Institute awarded Lothar A. Blatter, MD, Dr.med. (Physiology & Biophysics) and Kathrin Banach, PhD (Cardiology/Internal Medicine) a $2.7 million grant to research of calcium regulation in the atria that controls activity and contraction, but also arrhythmic activity and atrial fibrillation. In the heart contraction is controlled by calcium ions that are released from intracellular calcium stores. This calcium release occurs through two different ion channels, termed the ryanodine receptor and the IP3 receptor. The importance of the IP3 receptor is controversial, however there is growing evidence, established by the PIs of this study, that IP3 receptor dysfunction causes atrial rhythm disorders. In this study the PIs will investigate the novel hypothesis that atrial IP3 receptors are co-regulated by the cellular messenger IP3 and reactive oxygen species in defined cellular signaling domains. The understanding of the IP3 receptor regulatory mechanisms will provide the basis for the development of novel strategies for prevention and treatment of atrial fibrillation.

Rush Announcement - Read More...

Grant on NIH Reporter - Read More...

Josefina Ramos-Franco, MD, PhD is now an associate professor. Congratulations on her promotion!

Lothar A. Blatter, M.D., Dr.med., was named the John H. and Margaret V. Krehbiel Professor of Cardiology, effective December 1, 2021.
Rush University News - Read More…

Xun Ai, MD, was named the John H. and Margaret V. Krehbiel Professor of Cardiology, effective July 1, 2021.  Read More...

Our department's Dr. Xun Ai led a Basic Science PPE donation drive to help support Rush's front line heroes during the Covid-19 pandemic.

Through the philanthropy of the faculty & staff of the Rush basic science departments, this drive ultimately collected $2,755 and donated about 3,000 surgical masks (FDA approved) and 3,000 gloves to the Rush supply chain on April 24, 2020.

The National Heart, Lung, and Blood Institute awarded Xun Ai, MD, associate professor, physiology and biophysics, Rush Medical College, a five-year, $2.4 million grant to research the link between atrial fibrillation and thrombogenesis. Xun Ai, MD, associate professor, physiology and biophysics, Rush Medical College, and her team seek to establish a previously unrecognized crosstalk between heart and platelets and uncover the role of cardiac JNK2 in the development of both atrial fibrillation and thrombogenesis. Researchers will use results of the study, Heart-platelet Crosstalk: JNK, AF, and Thrombogenesis, to form a foundation toward developing novel therapies to treat and prevent atrial fibrillation and stroke.

Thomas DeCoursey, PhD, Vladimir Cherny, PhD, Deri Morgan, PhD, and collaborators from Georgia recently identified the first proton channel gene from a snail.  Read more...

Chicago Tribune press release of Yuriana Aguilar, PhD.

Yuriana Aguilar, PhD is Following Her DREAM.

Brought to the U.S. as an undocumented immigrant when she was five, Yuriana earned a PhD and became a heart researcher – and an unexpected spokesperson for other immigrants...
Learn More

In this installment of the American Physiological Society (APS) Living History of Physiology series, Robert S. Eisenberg, PhD, discusses how he became interested in science, his most significant contributions to physiology and his most influential career mentors. He also offers advice to students starting out in science today. Dr. Eisenberg was interviewed by Martin Frank, PhD, at Rush Medical College in Chicago.