Skip to main content

Get Health Care
About
Giving
Find Faculty
Library
RUSH U Portal
I am a...
Select from the list below to customize your experience: Select a new category

I am a:

Education
Looking to take the next step in your career? RUSH University offers a wide range of education and training options, including nationally ranked academic programs.

Find a Program
- Colleges
- Quick Links
Admissions
Student Life
Experience what life is like at RUSH University, and discover what our supportive learning community has to offer.

Learn More About Student Life
- About the RUSH Experience
- Quick Links
Research
RUSH researchers are leading efforts to cure disease and promote health equity — in Chicago and around the world.

Learn More About Research
- About Our Research
- Quick Links

Get Health Care
About
Giving
Find Faculty
Library
RUSH U Portal
I am a...
Select from the list below to customize your experience: Select a new category

I am a:

Search RUSH University

Deri Morgan, PhD

Breadcrumb

Home
Deri Morgan, PhD

Home

Assistant Professor, Department of Physiology & Biophysics

Rush Medical College

Assistant Professor, Department of Physiology & Biophysics

Contact Information

Address: 1750 W. Harrison St., Suite 1245
Chicago, IL 60612
Phone:
(312) 942-7829
Fax:
(312) 942-8711
Email:
deri_morgan@rush.edu

Links

Print this Page

Research Profile

Off

PhD, University of Hertfordshire, England
BSc, Swansea University, Wales
As part of the DeCoursey lab, Deri Morgan, PhD, has been involved in research into the role of voltage gated proton channels (Hv1) for over a decade. The DeCoursey lab has observed the function of this intricate channel in the antibacterial function of white blood cells, the release of histamine and in potential pathophysiological roles in excessive proliferation of B cells in lymphocytic leukemia. They have also determined the role of this channel in bioluminescence produced by marine dinoflagellates. Current research is examining the role of Hv1 in breast cancer and determining its efficacy in bone metabolism due to its expression in osteoclasts. Alongside discovering functions of the channel, they have discovered many structure function aspects of the channel including residues that determine the channels selectivity and permeation mechanism, as well as the method that this channel enhances its activity due to phosphorylation.
Complete list of published work on PubMed

Complete list of published work on Scopus

DeCoursey, T.E., D. Morgan, and V.V. Cherny. (2003). The voltage dependence of NADPH oxidase reveals why phagocytes need proton channels. Nature. 422:531-534.

Morgan, D., V.V. Cherny, A. Finnegan, J. Bollinger, M.H. Gelb, and T.E. DeCoursey. (2007). Sustained activation of proton channels and NADPH oxidase in human eosinophils and murine granulocytes requires PKC but not cPLA2? activity. Journal of Physiology. 579:327-344.

Musset, B., M. Capasso, V.V. Cherny, D. Morgan, M. Bhamrah, M.J.S. Dyer, and T.E. DeCoursey. (2010). Identification of Thr29 as a critical phosphorylation site that activates the human proton channel Hvcn1 in leukocytes. Journal of Biological Chemistry. 285:5117-5121.

Morgan, D., M. Capasso, B. Musset, V.V. Cherny, E. Rios, M.J.S. Dyer, T.E. DeCoursey. (2009). Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis. Proceedings of the National Academy of Sciences, U.S.A. 106:18022-18027.

Musset, B., D. Morgan, V.V. Cherny, D.W. MacGlashan Jr, L.L. Thomas, E. Rios, T.E. DeCoursey. (2008) A pH-stabilizing role of voltage-gated proton channels in IgE-mediated activation of human basophils. Proceedings of the National Academy of Sciences, U.S.A. 105(31):11020-5.

Musset, B., S.M.E. Smith, S. Rajan, D. Morgan, V.V. Cherny, and T.E. DeCoursey. (2011). Aspartate 112 is the selectivity filter of the human voltage gated proton channel. Nature. 480:273-277.

Morgan, D., B. Musset, K. Kulleperuma, S.M.E. Smith, S. Rajan, V.V. Cherny, R. Pomes, T.E. DeCoursey. (2013). Peregrination of the selectivity filter delineates the pore of the human voltage gated proton channel hHV1. Journal of General Physiology. 142:625-640.
- MCB-1242985 DeCoursey (PI) S.M.E. Smith (co-PI) 09/01/2013-08/31/2017, Collaborative Research: Voltage-Gated Proton Channels in Dinoflagellates, Role: Co-investigator
- R01 GM102336 DeCoursey (PI) Smith (co-PI) 09/01/2013-04/30/2017, Selectivity and Permeation in the Human Voltage-gated Proton Channel, hHV1, Role: Co-investigator
- Bears Care Morgan (PI) 1/31/2014-1/31/2016, RTSC: The Role of Voltage-Gated Proton Channels in pH Regulation and Reactive Oxygen Species in Metastatic Breast Cancer Cells, Role: PI
- Gavers Community Cancer Fund Morgan (PI) 1/31/2014-1/31/2016, Role: PI

Main Section
- Colleges
- For Professionals
- For Students
- Resources
(312) 942-7100

RUSH University
600 S. Paulina St.
Chicago, Illinois 60612

Contact Us

Accessibility, Privacy & Harassment Policies

© 2024 RUSH University